STORRS - Drew Lock threw for 377 yards and five touchdowns and Missouri routed Connecticut 52-12 on Saturday night, winning back-to-back games for the first time since the start of the 2015 season.
Lock, who played just under three quarters, picked apart the nation's worst pass defense, finishing with a career high 31 completions on 37 attempts.
The Tigers (3-5) gave up a safety after an errant snap on the opening drive, then scored on their next five possessions to lead 31-5 at halftime.
Lock completed 14 of 15 passes in the first quarter, three of them for touchdowns, including two to freshman tight end Albert Okwuegbunam.
He also hit J'Mon Moore for two scores and hooked up with Johnathon Johnson for a 72-yard catch and run in the third quarter.
The Tigers had 583 yards of offense, 408 through the air.
Bryant Shirreffs completed 19 of 39 passes for 202 yards for UConn (3-5), but was sacked five times.
Missouri: Lock becomes the first Missouri quarterback to throw for at least five touchdowns five times. He has 7,298 yards passing and now trails only Brad Smith (8,799 yards) and Chase Daniel (12,515 yards) on Missouri's all-time passing list. Over his last five games, the junior is 114-for-166 passing for 1,668 yards. He has thrown 20 touchdowns and just three interceptions.
UConn: The Huskies were coming off back-to-back wins over Temple and Tulsa, but have not won win three in a row since 2015. UConn has now given up more than 350 yards passing to six of its eight opponents.
Missouri: The Tigers return home to resume SEC play by hosting Florida next Saturday.
UConn: The Huskies begin the toughest stretch of their schedule by hosting No. 17 South Florida next week in a game rescheduled from September because of Hurricane Irma. The Bulls are coming off their first loss of the season. The Huskies then travel to the sunshine state to face No. 18 UCF.